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Development of a transoral robotic surgery program in Canada

AbstractDue to significant differences in healthcare structure between the United States and Canada, there are unique barriers to adopting new medical technology in Canada. In this article, we describe...

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Does HPV type affect outcome in oropharyngeal cancer?

AbstractBackgroundAn epidemic of human papillomavirus (HPV)-related oropharyngeal squamous cell cancer (OPSCC) has been reported worldwide largely due to oral infection with HPV type-16, which is...

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Exploiting high-throughput cell line drug screening studies to identify...

AbstractBackgroundThere is an urgent need for better therapeutics in head and neck squamous cell cancer (HNSCC) to improve survival and decrease treatment morbidity. Recent advances in high-throughput...

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A Stable Parametric Finite Element Discretization of Two-Phase Navier–Stokes...

AbstractWe present a parametric finite element approximation of two-phase flow. This free boundary problem is given by the Navier–Stokes equations in the two phases, which are coupled via jump...

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Two-Dimensional State Sum Models and Spin Structures

AbstractThe state sum models in two dimensions introduced by Fukuma, Hosono and Kawai are generalised by allowing algebraic data from a non-symmetric Frobenius algebra. Without any further data, this...

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Feasibility of Targeting PIK3CA Mutations in Head and Neck Squamous Cell...

AbstractPIK3CA is the only frequently-mutated, directly druggable oncogene in head and neck squamous cell carcinoma (HNSCC). However, it is unclear if a molecularly-driven intervention trial can be...

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A stable numerical method for the dynamics of fluidic membranes

AbstractWe develop a finite element scheme to approximate the dynamics of two and three dimensional fluidic membranes in Navier–Stokes flow. Local inextensibility of the membrane is ensured by solving...

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Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts...

AbstractBackgroundEpithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies. Herein, we investigated the efficacy of an...

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The prevalence of human papillomavirus in pediatric tonsils: a systematic...

AbstractBackgroundHPV-related head and neck cancer rates have been increasing in recent years, with the tonsils being the most commonly affected site. However, the current rate of HPV infection in the...

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Variational discretization of axisymmetric curvature flows

AbstractWe present natural axisymmetric variants of schemes for curvature flows introduced earlier by the present authors and analyze them in detail. Although numerical methods for geometric flows have...

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Genomic and human papillomavirus profiling of an oral cancer cohort...

AbtractBackgroundThe genomic landscape of head and neck cancer has been reported through The Cancer Genome Atlas project. We attempt to determine if high-risk human papillomavirus (HPV) or frequently...

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TAM family receptors in conjunction with MAPK signalling are involved in...

AbstractBackgroundAberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical...

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Modern treatment outcomes for early T-stage oropharyngeal cancer treated with...

AbstractBackgroundTransoral surgery (TOS), particularly transoral robotic surgery (TORS) has become the preferred modality in the United States for the treatment of early stage oropharyngeal cancer,...

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Empirical Shaft Resistance of Driven Piles Penetrating Weak Rock

AbstractIn this paper, an empirical relationship between the Unconfined Compressive Strength (UCS) of intact rock and the unit shaft resistance of piles penetrating rock is investigated. A growing...

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Low expression of NSD1 , NSD2 , and NSD3 define a subset of human...

AbstractBackgroundFrequent mutations in the nuclear receptor binding SET domain protein 1 (NSD1) gene have been observed in head and neck squamous cell carcinomas (HNSCC). NSD1 encodes a histone 3...

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Introduction and expression of PIK3CAE545K in a papillary thyroid cancer...

AbstractAnaplastic thyroid cancer (ATC) is a rare, aggressive form of undifferentiated thyroid cancer, which exhibits rapid progression and is almost universally fatal. At least a subset of ATC is...

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Impaired H3K36 methylation defines a subset of head and neck squamous cell...

Nada Jabado, Jacek Majewski and colleagues identify mutations in multiple histone H3 genes causing recurrent p.Lys36Met alterations in head and neck squamous cell carcinomas. They show that tumors with...

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Translational pharmacology of an inhaled small molecule αvβ6 integrin...

AbstractThe αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF)....

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Proteome and phosphoproteome signatures of recurrence for HPV+ head and neck...

AbstractBackgroundHead and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and the human papillomavirus (HPV+)-driven subtype is the fastest rising cancer in North...

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In vivo tracking of adenoviral-transduced iron oxide-labeled bone...

AbstractBackgroundDespite widespread study of dendritic cell (DC)-based cancer immunotherapies, the in vivo postinjection fate of DC remains largely unknown. Due in part to a lack of quantifiable...

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